Tegafur, Gimeracil and Oteracil Potassium capsules 20mg suppliers & manufacturers

Product Name (En): Tegafur, Gimeracil and Oteracil Potassium Capsules, TS-1, S-1, Teysuno

Nombre del Producto: Tegafur, gimeracil y oteracilo potasio capsulas
Specification: 20mg
Package: 14caps / blister / box, 28caps / blister / box, 42caps / blister / box
Standard: State standard

 

Introduction Hard capsule, a white or similar white particles or powder inside.    Indications Gastric cancer, colorectal cancer, head and neck cancers, non-small-cell lung cancer, inoperable or recurrent breast cancer, pancreatic cancer, and biliary tract cancer ..   Ingredients Tegafur: 20mg, Gimeracil: 5.8mg, Oteracil potassium: 19.6mg ;.   Use & Dosage Usually, the standard doses below are defined as the initial dose (single dose) for adults according to body surface area. TS-1 is administered twice daily, after breakfast and after the evening meal, for 28 consecutive days, followed by a 14- day rest. This is regarded as one course of the regimen.   Body surface area (m2) Initial dose (tegafur equivalent)                <1.25 40 mg each time     1.25 - <1.5 50 mg each time  ≥ 1.5 60 mg each time . The initial dose can be decreased or increased according to the patient's condition The doses are staged thus: 40 mg, 50 mg, 60 mg, and 75 mg If no drug-induced abnormalities in laboratory findings (hematological tests, liver and renal function. tests) and no gastrointestinal symptoms occur, ie, the drug is not problematic in terms of safety, and it is decided to increase the dose, the initial dose can be increased one stage, with an upper limit of 75 mg. It can also be decreased by one stage, and the lower limit is 40 mg.   Clinical Pharmacology Mechanism Of Action Tegafur is the actual chemotherapeutic agent. It is a prodrug of the active substance fluorouracil (5-FU). Gimeracil inhibits the degradation of fluorouracil by reversibly blocking a dehydrogenase enzyme. This results in higher 5-FU levels and a prolonged half-life of the substance. Oteracil mainly stays in the gut because of its low permeability, where it reduces the production of 5-FU by blocking the enzyme orotate phosphoribosyltransferase. Lower 5-FU levels in the gut result in a lower gastrointestinal toxicity

Related Keywords:                                                                                    
China Tegafur, Gimeracil and Oteracil Potassium Capsules manufacturer, China Tegafur Capsules suppliers, Tegafur, Gimeracil and Oteracil Potassium Capsules from China professional pharmaceutical factory, Oncology Drugs, Oncology Nursing Drug, Oncology And Supplementary Drug, Oncology Drugs Manufacturers, Oncology Drugs Suppliers, China Oncology Drugs, Tegafur, Gimeracil and Oteracil Potassium Capsules